Alexander O. Oginsky

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Theranostic applications require coupling of diagnosis and therapy, a high degree of specificity and adaptability to delivery methods compatible with clinical practice. The tunable physical and biological effects of selective targeting and activation of plasmonic nanobubbles (PNB) were studied in a heterogeneous biological microenvironment of prostate(More)
The synergistic physical and biological effects of selective targeting and activation of plasmonic nanoparticles were studied for a transient vapor nanobubble mode. Simultaneous optical activation of two plasmon resonances in multi-nanoparticle clusters significantly improved the selectivity and efficacy of the nanobubble generation through and was termed(More)
BACKGROUND AND OBJECTIVES Photothermal (PT) responses of individual red blood cells (RBC) to short laser pulses may depend upon PT interactions at microscale. STUDY DESIGN/MATERIALS AND METHODS A sequence of identical short laser pulses (0.5 and 10 nanoseconds, 532 nm) was applied to individual RBCs, and their PT properties were analyzed at microscale in(More)
BACKGROUND The accuracy, selectivity, and safety of surgical and laser methods for tissue elimination are often limited at microscale. MATERIALS AND METHODS We developed a novel agent, the plasmonic nanobubble (PNB), for optically guided selective elimination of the target tissue with micrometer precision. PNBs were tested in vitro in the two different(More)
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