Alexander N. Mikov

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At present, the discovery of drugs based on animal venoms undergoes its rebirth: pharmaceutical companies start to accept gradually the potential of animal venoms as combinatorial libraries of biologically active compounds. Sea anemones are a group of animals that produce the most structurally versatile polypeptide venom components, which distinguish them(More)
Novel disulfide-containing polypeptide toxin was discovered in the venom of the Tibellus oblongus spider. We report on isolation, spatial structure determination and electrophysiological characterization of this 41-residue toxin, called ω-Tbo-IT1. It has an insect-toxic effect with LD50 19 μg/g in experiments on house fly Musca domestica larvae and with(More)
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