Alexander McKenzie

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We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals with severe hemophilia A and ten "control" genomes. We summarize the number of genetic variants emerging from a study of this(More)
We present a purely Eulerian framework for geometry processing of surfaces and foliations. Contrary to current Eulerian methods used in graphics, we use conservative methods and a variational interpretation, offering a unified framework for routine surface operations such as smoothing, offsetting, and animation. Computations are performed on a fixed(More)
Scientific computing is an increasingly crucial component of research in various disciplines. Despite its potential, exploration of the results is an often laborious task, owing to excessively large and verbose datasets output by typical simulation runs. Several approaches have been proposed to analyze, classify, and simplify such data to facilitate an(More)
In this paper, we present a numerical technique for performing Lie advection of arbitrary differential forms. Leveraging advances in high-resolution finite volume methods for scalar hyperbolic conservation laws, we first discretize the interior product (also called contraction) through integrals over Eulerian approximations of extrusions. This, along with(More)
Responses to social cues, such as pheromones, can be modified by genotype, physiology, or environmental context. Honey bee queens produce a pheromone (queen mandibular pheromone; QMP) which regulates aspects of worker bee behavior and physiology. Forager bees are less responsive to QMP than young bees engaged in brood care, suggesting that physiological(More)
The Lie derivative, and Exterior Calculus in general, is ubiquitous in the elegant geometric interpretation of many dynamical systems. We extend recent trends towards a Discrete Exterior Calculus by introducing a discrete framework for the Lie derivative defined on differential forms, including a WENO based numerical scheme for its implementation. The(More)
Terrain reconstruction from images is an ill-posed, yet commonly desired Structure from Motion task when com-positing visual effects into live-action photography. These surfaces are required for choreography of a scene, casting physically accurate shadows of CG elements, and occlusions. We present a novel framework for generating the geometry of landscapes(More)
reviewers for their discussions and comments. Abstract We present a purely Eulerian framework for geometry processing of surfaces and foliations. Contrary to current Eulerian methods used in graphics, we use conservative methods and a variational interpretation , offering a unified framework for routine surface operations such as smoothing, offsetting, and(More)
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