Alexander M. Walker

John D Seeger2
Tobias Kurth2
Daniel M Rosenberg1
Suzanne F Cook1
2John D Seeger
2Tobias Kurth
1Daniel M Rosenberg
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Observational studies often provide the only available information about treatment effects. Control of confounding, however, remains challenging. The authors compared five methods for evaluating the effect of tissue plasminogen activator on death among 6,269 ischemic stroke patients registered in a German stroke registry: multivariable logistic regression,(More)
BACKGROUND In observational research, propensity score techniques can be used to account for baseline differences between compared therapies. Although propensity scores are used increasingly often, their limitations in settings without complete data may not be recognized. OBJECTIVES We sought to evaluate the ability of propensity score matching to(More)
BACKGROUND We sought to quantify the impact of patient characteristics on complications and health care costs associated with influenza and influenza-like illness (ILI) in a nonelderly population. METHODS Patients with medical reimbursement claims for influenza in the 1996-1997 season were identified from the automated database of a large private New(More)
We developed a semi-automated active monitoring system that uses sequential matched-cohort analyses to assess drug safety across a distributed network of longitudinal electronic health-care data. In a retrospective analysis, we show that the system would have identified cerivastatin-induced rhabdomyolysis. In this study, we evaluated whether the system(More)
PURPOSE To describe how computer-assisted presentation of case data can lead experts to infer machine-implementable rules for case definition in electronic health records. As an illustration the technique has been applied to obtain a definition of acute liver dysfunction (ALD) in persons with inflammatory bowel disease (IBD). METHODS The technique(More)
BACKGROUND Pre-marketing clinical studies of tegaserod suggested an increased risk of abdominal surgery, particularly cholecystectomy. We sought to quantify the association between tegaserod use and the occurrence of abdominal or pelvic surgery, including cholecystectomy. METHODS This cohort study was conducted within an insured population. Tegaserod(More)
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