Alexander M. Jamieson

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A 36-yr-old woman was referred to the endocrine clinic for investigation of oligomenorrhea, hirsutism, and acne. She was plethoric and overweight with central fat distribution. Plasma cortisol was normal, but her adrenal glands were enlarged (CT scan). Urinary tetrahydrocortisone excretion rate was consistently high, raising the possibility of(More)
Glucocorticoid remediable aldosteronism (GRA) is an autosomal dominant cause of primary aldosteronism and high blood pressure resulting from a chimeric 11beta-hydroxylase/aldosterone synthase gene. Abnormal expression of aldosterone synthase causes primary aldosteronism, which can be inhibited by glucocorticoids. Diagnosis of GRA has depended on the(More)
Using alumatrane and silatrane as sources of silica and alumina, respectively, and potassium hydroxide as the hydrolytic agent, a very high purity K-loaded zeolite was synthesized for the first time, via sol–gel processing and microwave heating techniques. Because of the bulky trialkoxyamine ligands, which shield the silicon and aluminium atoms, both(More)
Glucocorticoid suppressible hyperaldosteronism (GSH) is an uncommon form of dominantly inherited hypertension. Presentation with hypertension and complications such as stroke in early life are well recognised. The use of a simple genetic test carried out on blood or placenta facilitates the detection of infants and children with GSH before the development(More)
Electrorheological (ER) properties under oscillatory shear of perchloric acid doped-poly(3-thiopheneacetic acid)/oil (P3TAA/silicone) suspensions have been investigated. The effects of electric field strength, silicone oil viscosity, and particle concentration were investigated. When the electric field strength reaches a critical value, the P3TAA-based ER(More)
The sensitivity of 18 strains of Naegleria fowleri to clotrimazole (Bay b5097) was tested. They showed minimal inhibitory concentrations in the range 0-03-0-125 mug/ml, and minimal amoebicidal concentrations in the range 0-125-0-25 mug/ml. Mice inoculated with N. fowleri were not protected from infection by doses of 100 mg clotrimazole/kg per day given for(More)
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