Alexander M. Jamieson

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PURPOSE To establish a HPLC assay for plasma losartan and its active metabolite EXP3174 to facilitate clinical pharmacokinetic studies. METHODS the HPLC system consisted of a 250 x 2 mm i.d. C18 reversed phase column preceded by a 4 x 4 mm guard column, a UV detector set at 254 nm, and an integrator. The mobile phase was a mixture of 0.01 M ammonium(More)
We demonstrate that very stable hydrogels can be formed in aqueous potassium chloride solution by mixing a well-known gelator (guanosine, G) with a nongelator of similar structure (2',3',5'-tri-O-acetylguanosine, TAcG), and through a variety of characterization methods including rheology, small-angle neutron scattering, differential scanning calorimetry,(More)
Using alumatrane and silatrane as sources of silica and alumina, respectively, and potassium hydroxide as the hydrolytic agent, a very high purity K-loaded zeolite was synthesized for the first time, via sol–gel processing and microwave heating techniques. Because of the bulky trialkoxyamine ligands, which shield the silicon and aluminium atoms, both(More)
The electrorheological creep response of PANI/silicone oil suspensions near the yield point is investigated using parallel plate rheometry. Controlled-stress, thixotropic loop experiments exhibit a pronounced hysteresis, from which we determined the static yield stress (sigma(y(static))), as the stress where onset of flow occurs on the upward part of the(More)
Polyaniline (PANI) was synthesized via oxidative coupling polymerization in acid conditions and de-doped in solution of ammonia. The electrorheological (ER) properties of the PANI/silicone oil suspensions were investigated in oscillatory shear as functions of electric field strength, particle concentration, and host fluid viscosity. Consistent with(More)
Pure silk fibroin (SF) hydrogel and polycarbazole/silk fibroin (SF/PCZ) hydrogels were fabricated by solvent casting technique to evaluate electromechanical responses, dielectric properties, and cantilever deflection properties as functions of electric field strength, SF concentration, glutaraldehyde concentration, and PCZ concentration in the blends.(More)
The mechanism of gelation of 50/50 w/w mixtures of guanosine (G) and 2',3',5'-tri-O-acetylguanosine (TAcG) in aqueous 0.354 M KCl was investigated using a combination of static light scattering (SLS), polarized and depolarized dynamic light scattering (VV and VH DLS), small-angle neutron and X-ray scattering (SANS and SAXS), and viscometric experiments. SLS(More)
The aim of the study was to compare the bronchodilatory effect of 2x50 microg salbutamol inhaled via Turbuhaler(R) as two consecutive doses compared with two divided doses (50+50 microg) at different time intervals. The study was of a randomized, double-blind, crossover design. The patients inhaled two doses of 50 microg salbutamol immediately after each(More)
The influence of polyethylene oxide (PEO) on the rheological properties of equimolar wormlike micellar solutions of hexadecyltrimethylammonium chloride (HTAC) and sodium salicylate (NaSal) is investigated, above the concentration where a micellar entanglement network is formed. PEO is known to have a temperature-dependent binding affinity for HTAC micelles.(More)