Alexander M. Hoffman

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We have investigated the role of the double-stranded RNA-dependent protein kinase gene (pkr) in the regulation of the heat shock response. We show that the pkr gene is essential for efficient activation of the heat shock response and that pkr disruption profoundly inhibits heat shock protein 70 (HSP70) synthesis and blocks the development of(More)
Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional serine/threonine protein kinase that controls a range of cellular functions, including proliferation. The biological properties of CaMKII are regulated by multi-site phosphorylation and targeting via interactions with specific proteins. To investigate the role specific CaMKII(More)
Mandatory continuing education is being widely debated or enacted by many certifying agencies and state licensing bodies as a key factor in recertification and relicensure. It is commonly believed that mandatory continuing education automatically means continued competency. Continuing education, along with some of the arguments that support its existence,(More)
The microtubule, F-actin and neurofilament networks play a critical role in neuronal cell morphogenesis, polarity and synaptic plasticity. Significantly, the assembly/disassembly and stability of these cytoskeletal networks is crucially modulated by protein phosphorylation and dephosphorylation events. Herein, we aim to more closely examine the role played(More)
Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional kinase that controls a range of cellular functions, including proliferation, differentiation and apoptosis. The biological properties of CaMKII are regulated by multi-site phosphorylation. However, the role that CaMKII phosphorylation plays in cancer cell metastasis has not been(More)
The purpose of this paper is to describe how professional excellence can be maintained by participation in continuing education, thus avoiding professional obsolescence, and to describe essential factors in planning programs. Health professionals must recognize that lifetime licensure in a health care field is no longer a viable method of operation.(More)
This article examines the views of graduate students who are aspiring or practicing school leaders and faculty from two university degree granting leadership preparation programs. Drawn from a larger mixed methods study, the authors focus here on survey results that show how these groups rated the effectiveness of 14 potential curricular dimensions drawn(More)
Ischaemia/excitotoxicity produces persistent activation of CaMKII (Ca2+-calmodulin stimulated protein kinase II) that initiates cell death. This study investigated the involvement of CaMKII phosphorylation at T286 and T253 in producing this persistent activation. In T286A-αCaMKII transgenic mice that lack the ability to phosphorylate αCaMKII at T286,(More)
In this paper the author reviews the process of planning as it relates to the implementation of a continuing education program for allied health professionals and reviews some of the literature of continuing education in order to discuss planning in its proper perspective. The author defines continuing education and discusses the planning and implementation(More)
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