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Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell, allowing the segregation of sometimes incompatible biochemical reactions into specific compartments with tailored microenvironments. On the flip side, these isolating membranes that crowd the interior of the cell, constitute a hindrance to the diffusion of metabolites(More)
Information Extraction (IE)-the problem of extracting structured information from unstructured text - has become the key enabler for many enterprise applications such as semantic search, business analytics and regulatory compliance. While rule-based IE systems are widely used in practice due to their well-known "explainability," developing high-quality(More)
The unfolded protein response (UPR) monitors the protein folding capacity of the endoplasmic reticulum (ER). In all organisms analyzed to date, the UPR drives transcriptional programs that allow cells to cope with ER stress. The non-conventional splicing of Hac1 (yeasts) and XBP1 (metazoans) mRNA, encoding orthologous UPR transcription activators, is(More)
This paper describes the design and implementation of a new interface prototype for live music mixing. The ColorDex system employs a completely new operational metaphor which allows the mix DJ to prepare up to <i>six</i> tracks at once, and perform mixes between up to <i>three</i> of those at a time. The basic premises of the design are: 1) Build a(More)
Understanding the diversity of animal signals requires knowledge of factors which may influence the different stages of communication, from the production of a signal by the sender up to the detection, identification and final decision-making in the receiver. We studied a Neotropical katydid (Docidocercus gigliotosi) which uses airborne sound for long(More)
BACKGROUND AND AIMS In most fruit crops, storage quality varies greatly between regions and seasons, causing significant commercial loss. Understanding the sources of this variability will contribute to the knowledge of fruit developmental physiology and may also benefit commercial fruit production via altered managements that reduce it or forecasts that(More)
— The importance of visualization in conveying knowledge is undisputed. For example, the rise and fall of stocks is processed and understood faster by examining the corresponding line graph than looking at the raw underlying numbers. For the effectiveness of this cognitive process several factors have been identified in research, like for example the(More)
  • Alexander Lang, Susanne Grether-Beck, Madhurendra Singh, Fabian Kuck, Sascha Jakob, Andreas Kefalas +18 others
  • 2016
Mammalian sirtuins are involved in the control of metabolism and life-span regulation. Here, we link the mitochondrial sirtuin SIRT4 with cellular senescence, skin aging, and mitochondrial dysfunction. SIRT4 expression significantly increased in human dermal fibroblasts undergoing replicative or stress-induced senescence triggered by UVB or(More)