Selective death of nigrostriatal neurons, which leads to Parkinson disease, is explained by misfolding of brain protein alpha-synuclein. Herein, we review the data supporting this concept, propose a scheme of events leading to synuclein-induced neuronal death, and discuss protein deacetylase sirtuins as new potential therapeutic targets involved in this… (More)
P-selectin is a cell adhesion molecule that is sequestered in Wcibel-Palade storage reservoirs within the vascular endolhelium and a granules in platelets. P-selectin is rapidly translocated to the vascular lumen after tissue injury to initiate the adhesion and activation of platelets and leu kocytes. We studied the histolÃ³gica! pattern of P-selectin… (More)
For patients with advanced Parkinson's disease who do not respond to levodopa anymore, neurosurgical intervention is the only option. Cell transplantation has not met expectations as yet. Deep brain stimulation is gaining ground and currently seems to be the most efficient, flexible, and safe procedure.
The binding of lactose repressor to non-operator DNA was studied by the modification of several DNA's, including glycosylated DNA, with dimethyl sulphate, which affects the minor and major grooves of DNA and single stranded DNA regions. The non-specific binding of the repressor to DNA protected the minor groove but apparently not the major groove of the DNA… (More)