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BACKGROUND Interleukin-17A is considered to be central to the pathogenesis of psoriasis. We evaluated secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe plaque psoriasis. METHODS In two phase 3, double-blind, 52-week trials, ERASURE (Efficacy of Response and Safety of Two Fixed Secukinumab Regimens in(More)
BACKGROUND Benefits of conversion from calcineurin inhibitor (CNI) to mammalian target of rapamycin inhibitor-based immunosuppression in long-term kidney transplant patients remain uncertain. METHODS ASCERTAIN was a 24-month, open-label, multicenter study. Kidney transplant patients more than 6 months posttransplant receiving CNI (baseline glomerular(More)
Secukinumab, a fully human anti-IL-17A monoclonal antibody, neutralizes IL-17A, a key cytokine in the pathogenesis of psoriasis. Efficacy and safety of secukinumab was evaluated in Japanese patients with moderate-to-severe plaque psoriasis as part of a large Phase 3 global study (ERASURE). In this 52-week, double-blind study (ClinicalTrials.gov Identifier:(More)
Nineteen indices characterizing the disproportionality in a parliament are studied. A classification of these indices is suggested, and computational experiments and an axiomatic approach are used to study their properties. Effects of the number of parties and the degree of disproportionality are considered. The indices are evaluated for parliamentary(More)
BACKGROUND Secukinumab is a human interleukin-17A antagonist indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. The objective of this analysis was to measure the treatment response on psoriasis-related itching, pain, and scaling via the Psoriasis Symptom Diary (PSD)(©). (More)
We propose a new method of the Single Transferable Vote (STV) and give a unified way to describe classic procedures (Gregory Method, Inclusive Gregory Method and Weighted Inclusive Gregory Method) as an iterative procedure. A modification for quota definition is proposed which improves theoretical properties of the procedures. The method is justified by a(More)