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Performing a voluntary action involves the anticipation of the intended effect of that action. Interaction with the environment also requires the allocation of attention. However, the effects of attention upon motor predictive processes remain unclear. Here we use a novel paradigm to investigate attention and motor prediction orthogonally. In an acquisition(More)
Obesity and mental stress are potent risk factors for cardiovascular disease but their relationship with each other is unclear. Resilience to stress may differ according to adiposity. Early studies that addressed this are difficult to interpret due to conflicting findings and limited methods. Recent advances in assessment of cardiovascular stress responses(More)
OBJECTIVE To test if the covariance of hypothalamus-pituitary-adrenal (HPA) axis and subjective-psychological responses to stress is dependent on different dynamics of these systems. Although stress theories typically assume substantial correlations of psychological and endocrine stress responses, studies have produced inconsistent results. One reason for(More)
  • Meredith S. Gregory, Caroline G. Hackett, Emma F. Abernathy, Karen S. Lee, Rebecca R. Saff, Andreas M. Hohlbaum +10 others
  • 2011
Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death of retinal ganglion cells (RGCs) occurs in all forms of glaucoma and accounts for the loss of vision, however the molecular mechanisms that cause RGC loss remain unclear. The pro-apoptotic molecule, Fas ligand, is a transmembrane protein that can be cleaved from(More)
Adverse fetal environments are associated with depression, reduced cognitive ability and increased stress responsiveness in later life, but underlying mechanisms are unknown. Environmental pressures on the fetus, resulting from variations in placental function and maternal nutrition, health and stress might alter neurodevelopment, promoting the development(More)
BACKGROUND Inverse associations of fetal growth with behavioural problems in childhood have been repeatedly reported, suggesting long-term effects of the prenatal developmental environment on behaviour later in life. However, no study so far has examined effects on temperament and potential developmental pathways. Temperamental traits may be particularly(More)
Literature data indicate that bone is a major storage organ for manganese (Mn), accounting for 43% of total body Mn. However, the kinetic nature of Mn in bone, especially the half-life (t(1/2)), remained unknown. This study was designed to understand the time-dependence of Mn distribution in rat bone after chronic oral exposure. Adult male rats received 50(More)
PURPOSE To demonstrate that combining the Montreal Imaging Stress Task (MIST) with real-time cardiac magnetic resonance imaging (MRI) allows detailed assessment of the cardiovascular mental stress response. MATERIALS AND METHODS 22 healthy volunteers (1:1 M:F, 26-64 years) underwent MRI during rest and the MIST. Real-time spiral phase contrast MR,(More)
Selective attention to a spatial location has shown enhanced perception and facilitate behavior for events at attended locations. However, selection relies not only on where but also when an event occurs. Recently, interest has turned to how intrinsic neural oscillations in the brain entrain to rhythms in our environment, and, stimuli appearing in or out of(More)
Behavioural studies have shown that when engaging in a visual task response facilitation to tactile stimuli at exogenously cued locations is diminished. Here we investigated behavioural and also neural correlates of tactile exogenous attention when participants either watched a visual stream (single task) or also detected targets in the visual stream (dual(More)