Alexander Hewer

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Tamoxifen is an effective agent preventing mammary carcinogenesis in rats but causing liver tumours. Idoxifene is a more potent antioestrogen and is effective in patients with advanced breast cancer. We therefore compared the effects of idoxifene with tamoxifen on mammary carcinogenesis and hepatic DNA adduct formation. To do this, we undertook a study(More)
We describe a minimally-supervised method for computing a statistical shape space model of the palate surface. The model is created from a corpus of volumetric magnetic resonance imaging (MRI) scans collected from 12 speakers. We extract a 3D mesh of the palate from each speaker, then train the model using principal component analysis (PCA). The palate(More)
Vocal tract magnetic resonance imaging (MRI) has become one of the preferred imaging modalities for the analysis of human speech production. However, the raw image data must be segmented before further analysis can take place. This paper describes a hybrid approach to extract a 3D tongue model from 3D or 2D MRI scans of the vocal tract during speech, which(More)
We present a multilinear statistical model of the human tongue that captures anatomical and tongue pose related shape variations separately. The model was derived from 3D magnetic resonance imaging data of 11 speakers sustaining speech related vocal tract configurations. The extraction was performed by using a minimally supervised method that uses as basis(More)
Alexander Hewer1 hewer@mia.uni-saarland.de Joachim Weickert1 weickert@mia.uni-saarland.de Tobias Scheffer2 t.scheffer@mx.uni-saarland.de Henning Seibert2 h.seibert@mx.uni-saarland.de Stefan Diebels2 s.diebels@mx.uni-saarland.de 1 Mathematical Image Analysis Group Saarland University, Campus E1.7 66041 Saarbrücken, Germany 2 Chair of Applied Mechanics(More)
We present an end-to-end text-to-speech (TTS) synthesis system that generates audio and synchronized tongue motion directly from text. This is achieved by adapting a 3D model of the tongue surface to an articulatory dataset and training a statistical parametric speech synthesis system directly on the tongue model parameters. We evaluate the model at every(More)
Für die kommenden 30 Jahre wird eine progrediente Alterung der Bevölkerung in den westlichen Industrienationen prognostiziert. Neben sozioökonomischen und gesellschaftlichen Effekten sind hierdurch Auswirkungen auf das Gesundheitssystem zu erwarten. Die vorliegende Arbeit betrachtet die Auswirkungen des demographischen Wandels auf stationäre Fallzahlen und(More)
We present an end-to-end text-to-speech (TTS) synthesis system that generates audio and synchronized tongue motion directly from text. This is achieved by adapting a statistical shape space model of the tongue surface to an articulatory speech corpus and training a speech synthesis system directly on the tongue model parameter weights. We focus our analysis(More)
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