Alexander Hasse

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A randomized clinical trial was undertaken to compare the effectiveness of two partial denture designs, one with I-bar (bar) and the other with circumferential retainers (circumferential), in 134 patients with Kennedy class I and class II edentulous conditions. A total of 30 partial dentures were considered failures, five because of abutment failures and 25(More)
The free microvasclar fibula and soft tissue transfer has become a widely used method to reconstruct the head and neck region. Only few reports focus on the donor site morbidity of purely mandibular reconstructions. On the basis of the hospital charts, a standardized patient interview and a standardized physical examination, the present study evaluates the(More)
The 5'-upstream region of the rat alpha-fetoprotein (AFP) gene strongly increased de novo methylation of an adjacent chloramphenicol acetyltransferase (CAT) gene upon transfection into F9 mouse embryonal carcinoma cells. The same effect was exerted by a distal 775-base pair (bp) fragment and by 300- and 1-kb fragments preceding the transcriptional start(More)
The incidence of ST segment depression during tooth extraction was significantly higher in patients with cardiac disease than it was in patients without cardiac disease, indicating that the cardiac patients experienced myocardial ischemia. The almost equivalent incidence of ST segment depression during anesthetic administration and surgery suggests that the(More)
This study compared the tactile sensitivity of splinted abutment and denture teeth of 16 fixed partial dentures (FPD) supported by blade implants and 16 removable partial dentures (RPD) in patients with Kennedy Class I and Class II edentulous conditions. No significant differences were noted between the tactile thresholds of the natural abutment teeth and(More)
STATEMENT OF PROBLEM There is no known data on the functional efficacy of different removable partial denture designs. PURPOSE This randomized clinical trial compared the masticatory performance of two commonly used designs in 118 patients who needed a unilateral or bilateral mandibular partial denture. MATERIAL AND METHODS One half of the patients(More)
Expression of the LAC9 gene from the yeast Kluyveromyces lactis in HepG2 human hepatoblastoma cells efficiently induced luciferase expression from reporter plasmids containing the four LAC9 binding sites from the K. lactis GAL1-GAL10 gene linked to a basal promoter. Induction was approximately 100fold and was dependent on the presence of the UAS sequence(More)
To study the formation of DNA methylation patterns, plasmids containing promoters of different strengths in front of the bacterial chloramphenicol acetyltransferase reporter gene were transfected into F9 mouse embryonal carcinoma cells. Methylation of the integrated plasmids as well as copy numbers and activities of the reporter gene were determined for(More)
PROBLEM Good scientific evidence is lacking on the impact of improvement in masticatory function after prosthodontic restoration of missing teeth. PURPOSE This study compares 1-week dietary intakes of 218 healthy, male patients, 111 patients restored with mandibular unilateral or bilateral distal base extension removable partial dentures and 107 patients(More)