Alexander H. J. Danser

Learn More
The existence of a local cardiovascular renin-angiotensin system (RAS) is often invoked to explain the long-term beneficial effects of RAS inhibitors in heart failure and hypertension. The implicit assumption is that all components of the RAS are synthesized in situ, so that local angiotensin II formation may occur independently of the circulating RAS.(More)
We and others have recently shown that angiotensin II can activate the sodium chloride cotransporter (NCC) through a WNK4–SPAK-dependent pathway. Because WNK4 was previously shown to be a negative regulator of NCC, it has been postulated that angiotensin II converts WNK4 to a positive regulator. Here, we ask whether aldosterone requires angiotensin II to(More)
Objective: To characterise the pharmacokinetics of adenosine 5′-triphosphate (ATP) in patients with lung cancer after i.v. administration of different ATP dosages. Methods: Twenty-eight patients received a total of 176 i.v. ATP courses of 30 h. Fifty-two infusions were given as low-dose infusions of 25–40 μg kg−1 min−1, 47 as middle-dose infusions of 45–60(More)
During hypovolemia and hyperkalemia, the kidneys defend homeostasis by Na(+) retention and K(+) secretion, respectively. Aldosterone mediates both effects, but it is unclear how the same hormone can evoke such different responses. To address this, we mimicked hypovolemia and hyperkalemia in four groups of rats with a control diet, low-Na(+) diet, high-K(+)(More)
Background: Apoptosis plays a key role in the pathogenesis of cardiac diseases. We examined the influence of the renin-angiotensin system (RAS) on different regulators of apoptosis using an isolated hemoperfused working porcine heart model of acute ischemia (2 h), followed by reperfusion (4 h). Methods and Results: 23 porcine hearts were randomized to 5(More)
Fibulins are extracellular matrix proteins associated with elastic fibres. Homozygous Fibulin-4 mutations lead to life-threatening abnormalities such as aortic aneurysms. Aortic aneurysms in Fibulin-4 mutant mice were associated with upregulation of TGF-β signalling. How Fibulin-4 deficiency leads to deregulation of the TGF-β pathway is largely unknown.(More)
Fibrinolysis, the counterpart of the coagulation system of the blood, is regulated by a number of proteins, which maintain a complicated nel:work of inhibitory and stimulatory reactions. Plasmin is the key enzyme in this process; it can degrade fibrin depositions such as blood clots. Since plasmin is a rather non-specific protease, and therefore a(More)
Metanocortins have various physiological actions on the brain. The recent cloning of neural melanecortin 0//(2) receptors Opened new avenues to study the effect of these ncuropeptides on the nervous system. We investigated the structure activity relations (SARs) of peptides derived from adrenecorticotropo hormone (ACrH) on cloned MC3, MC4 and MC5 receptors(More)
BACKGROUND The aim was to investigate the unknown mechanism of osmomediated natriuresis. This is the phenomenon by which hypertonic saline (HS) produces a larger natriuresis than isotonic saline (IS), despite the same sodium content. METHODS Seven healthy volunteers first received HS and then IS (both 3.85 mmol sodium/kg). To investigate the role of(More)