Alexander Gutfraind

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Relationships between entities in complex systems could be represented using the paradigm of networks. The network representation can then reveal the evolution, structure and dynamics of those systems. Frequently, obtaining the required scientific data about the networks is expensive or infeasible. In other words, the amount of available empirical data is(More)
IMPORTANCE Infection with the respiratory syncytial virus (RSV) is the leading cause of hospitalizations in children, accounting for more than 90,000 hospitalizations every year in the United States. For children who are at risk for severe RSV infections, the American Academy of Pediatrics recommends immunoprophylaxis with a series of up to 5 injections of(More)
The interdiction problem arises in a variety of areas including military logistics, infectious disease control, and counter-terrorism. In the typical formulation of network interdiction, the task of the interdictor is to find a set of edges in a weighted network such that the removal of those edges would maximally increase the cost to an evader of traveling(More)
Complex socioeconomic networks such as information, finance and even terrorist networks need resilience to cascades--to prevent the failure of a single node from causing a far-reaching domino effect. We show that terrorist and guerrilla networks are uniquely cascade-resilient while maintaining high efficiency, but they become more vulnerable beyond a(More)
BACKGROUND To combat the 2014-2015 Ebola virus disease (EVD) epidemic in West Africa, the World Health Organization urged the rapid evaluation of convalescent whole blood (CWB) and plasma (CP) transfusion therapy. However, the feasibility and likely impacts of broad implementation of transfusions are yet unknown. METHODS We extended an Ebola virus(More)
Major revolts have recently erupted in parts of the Middle East with substantial international repercussions. Predicting, coping with and winning those revolts have become a grave problem for many regimes and for world powers. We propose a new model of such revolts that describes their evolution by building on the classic Lanchester theory of combat. The(More)
Building resilience into today's complex infrastructures is critical to the daily functioning of society and its ability to withstand and recover from natural disasters, epidemics, and cyber-threats. This study proposes quantitative measures that capture and implement the definition of engineering resilience advanced by the National Academy of Sciences. The(More)
During the RNA World, organisms experienced high rates of genetic errors, which implies that there was strong evolutionary pressure to reduce the errors’ phenotypical impact by suitably structuring the still-evolving genetic code. Therefore, the relative rates of the various types of genetic errors should have left characteristic imprints in the structure(More)
Complex socio-economic networks such as transportation networks, information systems and even underground organizations are often designed for resilience to be able to function even if some of the nodes (e.g. hubs, routers, operatives etc.) are compromised by a human or natural adversary. In many cases the adversary threatens to cause a cascade where the(More)