Alexander Glennon Shearer

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EcoCyc ( provides a comprehensive encyclopedia of Escherichia coli biology. EcoCyc integrates information about the genome, genes and gene products; the metabolic network; and the regulatory network of E. coli. Recent EcoCyc developments include a new initiative to represent and curate all types of E. coli regulatory processes such as(More)
MOTIVATION Key problems for computational genomics include discovering novel pathways in genome data, and discovering functional interaction partners for genes to define new members of partially elucidated pathways. RESULTS We propose a novel method for the discovery of subsystems from annotated genomes. For each gene pair, a score measuring the(More)
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