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mDia mediates Rho-regulated formation and orientation of stable microtubules
TLDR
The results show that mDia is sufficient to generate and orient stable microtubules, and indicate that Dia-related formins are part of a conserved pathway that regulates the dynamics of microtubule ends. Expand
Mechanisms Determining the Morphology of the Peripheral ER
TLDR
Several sheet-enriched membrane proteins in the mammalian ER are identified, including proteins that translocate and modify newly synthesized polypeptides, as well as coiled-coil membrane proteins that are highly upregulated in cells with proliferated ER sheets, all of which are localized by membrane-bound polysomes. Expand
Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling
TLDR
It is reported that integrin-mediated activation of focal adhesion kinase (FAK) at the leading edge is required for MT stabilization by the Rho-mDia signaling pathway in mouse fibroblasts. Expand
Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization
TLDR
It is shown that serum and the serum lipid, lysophosphatidic acid (LPA), increased Cdc42 GTP levels and triggeredMTOC reorientation in serum-starved wounded monolayers of 3T3 fibroblasts, establishing an LPA/Cdc42 signaling pathway that regulates MTOC re orientation in a dynein-dependent manner. Expand
The Case for Junk DNA
TLDR
The excitement and subsequent backlash of the ENCODE claims served to illustrate the widespread interest among scientists and nonspecialists in determining how much of the human genome is functionally significant at the organism level. Expand
The Signal Sequence Coding Region Promotes Nuclear Export of mRNA
TLDR
The surprising observation that the signal sequence coding region (SSCR) can serve as a nuclear export signal of an mRNA that lacks an intron or functional cap is made and suggests a link between nuclear export and membrane targeting of mRNAs. Expand
Non-coding RNA: what is functional and what is junk?
TLDR
How to determine whether any given ncRNA has a function is discussed, and it is advocated that in the absence of any such data, the appropriate null hypothesis is that the RNA in question is junk. Expand
Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation.
TLDR
The garlic-derived compound SAMC exerts antiproliferative effects by binding directly to tubulin and disrupting the MT assembly, thus arresting cells in mitosis and triggering JNK1 and caspase-3 signaling pathways that lead to apoptosis. Expand
p180 Promotes the Ribosome-Independent Localization of a Subset of mRNA to the Endoplasmic Reticulum
The localization of many secretory mRNAs to the endoplasmic reticulum does not require ribosomes or translation, but is instead promoted by p180, an abundant, membrane-bound protein that likely bindsExpand
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