Alexander F Hoffman

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Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products

Michael Heinrich Baumann, John S. Partilla, +11 authors Charles W. Schindler
Neuropsychopharmacology
2013

The abuse of psychoactive ‘bath salts’ containing cathinones such as 3,4-methylenedioxypyrovalerone (MDPV) is a growing public health concern, yet little is known about their pharmacology. Here, we… (More)

Cocaine drives aversive conditioning via delayed activation of dopamine-responsive habenular and midbrain pathways.

Thomas Clayton Jhou, Cameron H. Good, +6 authors Satoshi Ikemoto
The Journal of neuroscience : the official…
2013

Many strong rewards, including abused drugs, also produce aversive effects that are poorly understood. For example, cocaine can produce aversive conditioning after its rewarding effects have… (More)

Marijuana and cannabinoid regulation of brain reward circuits.

Carl R. Lupica, Arthur C Riegel, Alexander F Hoffman
British journal of pharmacology
2004

The reward circuitry of the brain consists of neurons that synaptically connect a wide variety of nuclei. Of these brain regions, the ventral tegmental area (VTA) and the nucleus accumbens (NAc) play… (More)

Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons.

Carl R. Lupica, James A. Bell, Alexander F Hoffman, Patricia L. Watson
Journal of neurophysiology
2001

Intrinsic GABAergic interneurons provide inhibitory input to the principal neurons of the hippocampus. The majority of interneurons located in stratum oriens (s.o.) of the CA1 region express the… (More)

Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus.

Alexander F Hoffman, Carl R. Lupica
The Journal of neuroscience : the official…
2000

The localization of cannabinoid (CB) receptors to GABAergic interneurons in the hippocampus indicates that CBs may modulate GABAergic function and thereby mediate some of the disruptive effects of… (More)

Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure.

Alexander F Hoffman, Murat Oz, Tara Caulder, Carl R. Lupica
The Journal of neuroscience : the official…
2003

The rewarding properties of the psychoactive constituents of marijuana, termed "cannabinoids," may reflect actions on synaptic transmission in the nucleus accumbens (NAc). Furthermore, long-term… (More)

Dopaminergic and glutamatergic microdomains within a subset of rodent mesoaccumbens axons

Shiliang Deng John A. Deskins Tami J. Gurley Brian C. Hill Zhang, Jia Qi, +6 authors Marisela Morales
Nature Neuroscience
2015

Mesoaccumbens fibers are thought to co-release dopamine and glutamate. However, the mechanism is unclear, and co-release by mesoaccumbens fibers has not been documented. Using electron microcopy, we… (More)

Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation.

Alexander F Hoffman, Murat Oz, Ruiqin Yang, Aron H. Lichtman, Carl R. Lupica
Learning & memory
2007

Memory deficits produced by marijuana arise partly via interaction of the psychoactive component, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), with cannabinoid receptors in the hippocampus. Although… (More)

A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons

Jia Qi, Shiliang Deng John A. Deskins Tami J. Gurley Brian C. Hill Zhang, +6 authors Marisela Morales
Nature communications
2014

Electrical stimulation of the dorsal raphe (DR) and ventral tegmental area (VTA) activates the fibres of the same reward pathway but the phenotype of this pathway and the direction of the… (More)

Single rodent mesohabenular axons release glutamate and GABA

David H Root, Carlos A Mejias-Aponte, +4 authors Marisela Morales
Nature Neuroscience
2014

The lateral habenula (LHb) is involved in reward, aversion, addiction and depression through descending interactions with several brain structures, including the ventral tegmental area (VTA). The VTA… (More)

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