Alexander C. Matte

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The crystal structure of ATP-dependent phosphoenolpyruvate carboxykinase (ATP-oxaloacetate carboxy-lyase, (transphosphorylating), E.C. 4.1.1.49; PCK) from Escherichia coli strain K12 has been determined using a combination of multiple isomorphous replacement, density modification, and partial model phase combination, and refined to a conventional R-index of(More)
We report the 1.8 A crystal structure of adenosine triphosphate (ATP)-magnesium-oxalate bound phosphoenolpyruvate carboxykinase (PCK) from Escherichia coli. ATP binding induces a 20 degree hinge-like rotation of the N- and C-terminal domains which closes the active-site cleft. PCK possesses a novel nucleotide-binding fold, particularly in the(More)
Understanding how phosphoryl transfer is accomplished by kinases, a ubiquitous group of enzymes, is central to many biochemical processes. Qualitative analysis of the crystal structures of enzyme-substrate complexes of kinases reveals structural features of these enzymes important to phosphoryl transfer. Recently determined crystal structures which mimic(More)
The literature reports on antiandrogenic and antigonadotropic effects of cyproterone acetate (CA) and on its inhibitory influence on the structure and function of the testis and reduction of the sexual drive in man and animals. No one has as yet been able to confirm a reduction of aggression which could be expected under CA. Isolated male wild mice received(More)
  • A C Matte
  • Pharmacology, biochemistry, and behavior
  • 1981
Aggressive behavior, motor activity and defecation were examined simultaneously in wild male mice following daily growth hormone (GH) administration. GH was found to increase isolation-induced aggression by increasing fighting duration and decreasing latency to fight. There was no influence on non-aggressive motor activity nor on the defecation rate, a(More)
The effects of i.p. administration of a hashish solution on the fighting behaviour of isolated male wild house-mice were examined in a qualitative and quantitative behavioural study. Daily doses of 20 mg/kg led to increased aggressiveness as shown in the different parameters. This was demonstrated in a decrease, significant at the 2% level, of the latent(More)
A method is described for quantitating isolation-induced aggression in wild male mice by measuring coarse motor activity. It is based on the operational definition that aggression is the form of motor activity in which two (or more) animals are involved in behaviour patterns, such as physical attack and/or defence including pursuit and flight. Both coarse(More)