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Novel ciliate lipases for enzyme replacement during exocrine pancreatic insufficiency
TLDR
Three novel ciliate lipases derived from Tetrahymena thermophila are cloned and analyzed and are promising candidates for an improved enzyme replacement therapy for exocrine pancreatic insufficiency.
Long term follow-up of a simplified and less burdened pancreatic duct ligation model of exocrine pancreatic insufficiency in Goettingen Minipigs
TLDR
Pancreatic duct ligation in minipigs is an excellent method of inducing exocrine pancreatic insufficiency and has the potential to be used in long-term EPI studies with up to 100 weeks post-OP without supplementation with enzymes and vitamins.
Long - term follow up of a simplified and less burdened pancreatic duct ligation model of exocrine pancreatic insufficiency in Goettingen Minipigs
BackgroundPancreatic duct ligation in a minipig model leads to exocrine pancreatic insufficiency (EPI). This allows studies of digestive processes and pancreatic enzyme replacement therapies