Alexander Brand

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BACKGROUND GPs have many patients with gastrointestinal discomfort. Among bowel-related complaints, the sign of rectal bleeding is of particular importance in patients aged 50 years and above, as it can be an early sign for serious bowel diseases such as colon carcinoma. Despite many guidelines offered to GPs for screening and early detection of colorectal(More)
The alignment of the lower limb in high tibial osteotomy (HTO) or total knee arthroplasty (TKA) must be determined intraoperatively. One way to do so is to deform the mechanical axis deviation (MAD), for which a tolerance measurement of 10 mm is widely accepted. Many techniques are proposed in clinical practice such as visual inspection, cable method, grid(More)
It has long been suggested that retroviral infection may play a role in the pathogenesis of autoimmune rheumatic disease. Particles resembling retroviruses have been reported in tissue from patients with Sjögren's syndrome, lupus and rheumatoid arthritis, and molecular mimicry between retroviral antigens and host proteins has been proposed as a mechanism of(More)
A number of studies have found increased levels of antibodies to human endogenous retroviruses (HERVs) in autoimmune rheumatic diseases. It is not clear whether this immune response is driven by the HERV itself or by cross-reactions with an exogenous virus or an autoantigen. To address this question, we examined the antibody response to the Env protein of(More)
The use of fractionated reclaimed asphalt pavement (FRAP) was investigated as a partial replacement (0%, 20%, 35%, and 50%) of virgin coarse aggregate in a ternary blend concrete containing cement, slag, and fly ash. The results demonstrated that up to 50% FRAP may be feasible in a concrete to meet the Illinois Department of Transportation strength(More)
Avascular necrosis (AVN) is an emerging complication of HIV infection. The incidence of AVN in HIV patients is greater than the general population. Although the incidence has increased in the HAART era, the aetiology remains unclear. We report our experience of AVN from our tertiary referral HIV centre and evaluate risk factors for its development. Review(More)
Intelligent compaction is gaining attention for its ability to spatially map the compaction effort of a pavement support layer, and it has also been shown to be able to detect areas of nonuniform compaction, which raises the issue of what the effects of a nonuniform support condition are on the stresses and deflections in a rigid pavement. This study(More)
Digital holographic microscopy (DHM) is a surface topography measurement technique with reported sub-nanometer vertical resolution. Although it has been made commercially available recently, few studies have evaluated the uncertainty or noise in the phase measurement by the DHM. As current research is using the DHM to monitor surface topography changes of(More)
Few studies have focused on the effect of recycled materials on the concrete slab load capacity. This study used virgin and recycled aggregates—fractionated reclaimed asphalt pavement (FRAP) and recycled concrete aggregate (RCA)—and by-product cementitious materials—ground granulated blast furnace slag and fly ash—to cast and test the load capacity of(More)
Determination of lower limb alignment is a prerequisite for successful orthopedic surgical treatment. Traditional methods include the electrocautery cord, alignment rod, or axis board which rely solely on C-arm fluoroscopy navigation and are radiation intensive. To assess a new augmented reality technology in determining lower limb alignment. A(More)
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