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Classification of Tumor Histology via Morphometric Context

• Hang Chang, Alexander Borowsky, Paul T. Spellman, Bahram Parvin
• 2013 IEEE Conference on Computer Vision and…
• 2013

Image-based classification of tissue histology, in terms of different components (e.g., normal signature, categories of aberrant signatures), provides a series of indices for tumor composition.… (More)

Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.

• Michael Ittmann, Jiaoti Huang, +11 authors Robert Cardiff
• Cancer research
• 2013

Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue culture models are extremely useful in… (More)

Invariant Delineation of Nuclear Architecture in Glioblastoma Multiforme for Clinical and Molecular Association

• Hang Chang, Ju Han, +4 authors Bahram Parvin
• IEEE Transactions on Medical Imaging
• 2013

Automated analysis of whole mount tissue sections can provide insights into tumor subtypes and the underlying molecular basis of neoplasm. However, since tumor sections are collected from different… (More)

Classification of tumor histopathology via sparse feature learning

• Nandita Nayak, Hang Chang, Alexander Borowsky, Paul T. Spellman, Bahram Parvin
• 2013 IEEE 10th International Symposium on…
• 2013

Our goal is to decompose whole slide images (WSI) of histology sections into distinct patches (e.g., viable tumor, necrosis) so that statistics of distinct histopathology can be linked with the… (More)

Evidence for Phenotypic Plasticity in Aggressive Triple-Negative Breast Cancer: Human Biology Is Recapitulated by a Novel Model System

• Nicholas C. D’Amato, Julie Hanson Ostrander, +14 authors Victoria L. Seewaldt
• PloS one
• 2012

Breast cancers with a basal-like gene signature are primarily triple-negative, frequently metastatic, and carry a poor prognosis. Basal-like breast cancers are enriched for markers of breast cancer… (More)

Therapy-induced malignant neoplasms in Nf1 mutant mice.

• Richard C. Chao, Urszula Pyzel, +11 authors Kevin M. Shannon
• Cancer cell
• 2005

Therapy-induced cancers are a severe complication of genotoxic therapies. We used heterozygous Nf1 mutant mice as a sensitized genetic background to investigate tumor induction by radiation (RAD) and… (More)

Batch-invariant nuclear segmentation in whole mount histology sections

• Hang Chang, Leandro A. Loss, Paul T. Spellman, Alexander Borowsky, Bahram Parvin
• 2012 9th IEEE International Symposium on…
• 2012

The Cancer Genome Atlas (TCGA) provides a rich repository of whole mount tumor sections that are collected from different laboratories. However, there are a significant amount of technical and… (More)

Learning invariant features of tumor signatures

• Quoc V. Le, Ju Han, Joe W. Gray, Paul T. Spellman, Alexander Borowsky, Bahram Parvin
• 2012 9th IEEE International Symposium on…
• 2012

We present a novel method for automated learning of features from unlabeled image patches for classification of tumor architecture. In contrast to previous manually-designed feature detectors (e.g.,… (More)

Stacked Predictive Sparse Decomposition for Classification of Histology Sections

• Hang Chang, Yin Zhou, Alexander Borowsky, Kenneth E. Barner, Paul T. Spellman, Bahram Parvin
• International Journal of Computer Vision
• 2014

Image-based classification of histology sections, in terms of distinct components (e.g., tumor, stroma, normal), provides a series of indices for histology composition (e.g., the percentage of each… (More)

A Global Coexpression Network Approach for Connecting Genes to Specialized Metabolic Pathways in Plants.

• Jennifer H Wisecaver, Alexander Borowsky, Vered Tzin, Georg Jander, Daniel J. Kliebenstein, Antonis Rokas
• The Plant cell
• 2017

Plants produce diverse specialized metabolites (SMs), but the genes responsible for their production and regulation remain largely unknown, hindering efforts to tap plant pharmacopeia. Given that… (More)

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