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  • Alexander Beeser, Zahara M. Jaffer, Clemens Hofmann, Jonathan Chernoff
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2005 (First Publication: 4 November 2005)
  • The canonical extracellular-regulated kinase (ERK) signaling cascade, consisting of the Ras-Raf-Mek-ERK module, is critically important to many cellular functions. Although the general mechanism ofExpand
  • Lucinda F. Reynolds, Carine de Bettignies, Trisha Norton, Alexander Beeser, Jonathan Chernoff, Victor L. J. Tybulewicz
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2004 (First Publication: 30 April 2004)
  • Vav1 is a signaling protein required for both positive and negative selection of CD4+CD8+ double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection.Expand
  • Alina De la Mota-Peynado, Jonathan Chernoff, Alexander Beeser
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2011 (First Publication: 11 February 2011)
  • The class I p21-activated kinases (Pak1–3) regulate many essential biological processes, including cytoskeletal rearrangement, cell cycle progression, apoptosis, and cellular transformation. AlthoughExpand
  • Minna Thullberg, Annica K. B. Gad, Alexander Beeser, Jonathan Chernoff, Staffan Strömblad
  • Biology, Medicine
  • Oncogene
  • 2007 (First Publication: 1 March 2007)
  • p21-activated kinase 1 (PAK1) is a mediator of downstream signaling from the small GTPases Rac and Cdc42. In its inactive state, PAK1 forms a homodimer where two kinases inhibit each other in trans.Expand