Alexander Agrifoglio

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Severely burned patients have altered drug pharmacokinetics (PKs), but it is unclear how different they are from those in other critically ill patient groups. The aim of the present study was to compare the population pharmacokinetics of micafungin in the plasma and burn eschar of severely burned patients with those of micafungin in the plasma and(More)
Functional endoscopic sinus surgery can be associated with iatrogenic complications. Some anatomical structures have been identified this clinically as specific danger sites. The aim of this study was to confirm and to compare these clinical data with measurements of the bone resistance of the sphenoid and ethmoid walls and to point out regions that have(More)
The evolution of rhino-sinusal endoscopy and the progress in endonasal surgery under endoscopic guidance, justifies a review of the ethmoid anatomy. A simple and logical scheme of the ethmoid bone is presented. The observer has to develop an "endoscopic eye" since the panoramic view offered by the optics modifies the image. Special attention is drawn upon(More)
Acute kidney injury (AKI) is an important complication in burn patients. Recently, it has been recommended that hydroxyethyl starch (HES) be avoided in burn patients because it increases the incidence of AKI. Our purpose was to study incidence of AKI in critically ill burn patients resuscitated with Ringer's solution and supplements of HES. We conducted an(More)