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Modern concepts of neurophysiological mechanisms of the brain reinforcing systems are reviewed from A.A. Ukhtomsky's concept of dominanta. The brain mesocorticolimbic system was shown to play a key role in functioning of the brain reinforcing systems. Morphological and neurochemical organisation of this system determining the emotional sphere, was studied.(More)
The present study aimed to compare the effects of various abused drugs on threshold current intensities and the breaking points of intracranial self-stimulation. Effects of morphine (1-10 mg/kg, s.c.), d-amphetamine (0.3-3.2 mg/kg, i.p.), nicotine (0.1-3.2 mg/kg, s.c.), ethanol (0.6-2.4 g/kg, p.o.), caffeine (1-20 mg/kg, i.p.) and phencyclidine (0.3-5.6(More)
Recent progress in studies of dopaminergic transmission in the brain has resulted from significant advances in experimental neurophysiology and biochemistry, and the wide use of neurotropic substances with dopaminergic activity in many CNS diseases. The development of neuroanatomical study methods has led to the identification of the major neurochemical(More)
The reinforcing properties of different doses of amphetamine (1 and 5 mg/kg) were examined using two variants of self-stimulation reaction (in the Skinner box and locomotor self-stimulation in a shuttle box) and place preference test. Amphetamine in dose of 1 mg/kg increased the frequency of self-stimulation in the Skinner box and prolonged the time of rat(More)
We studied morphofunctional changes in structures of the mesocorticolimbic system of rat brain upon long-term (5 months) ethanol intoxication. Alcoholization reduced the volume and specific density of neurons in the substantia nigra and ventral tegmental area. The density of neurogliocytes in the substantia nigra and ventral tegmental area increased.(More)
14 Corticoliberin or corticotropin-releasing factor (CRF) was isolated in 1981 [15]. It is a single-chain peptide consisting of 41 amino acid residues; the molecular weight is 4670 Da [12]. Corticoliberin displays a wide species specificity [12] and contributes into a superfamily of NRF peptides [10]. In the brain, the CRF gene expression is regulated by(More)
Surgical treatment was given to 45 patients with overactive bladder: transurethral detrusorotomy was made in 21 patients (group 1), bladder hydrodilation (BH) was made in 24 patients (group 2). Detrusorotomy was performed by transurethral median cut of the bladder posterior wall by needle electrode leading to destroyment of intramural sympathic and(More)
Amphetamine (1 mg/kg) promoted a pedal self-stimulation of lateral hypothalamus of Wistar rats in the Skinner box. An unipolar lesion of medical prefrontal cortex with kainic acid 10-14 days prior to an experiment did not prevent the facilitating effect of amphetamine on self-stimulation, though the levels of hypothalamic noradrenaline and dopamine are 43%(More)
Wistar male rats were injected intraperitoneally for 4 days in elevated doses with: (1) physiological saline (control; 0.1 - 0.2 - 0.4 - 0.8 ml/rat), (2) amphetamine (0.5 - 1.0 - 2.0 - 4.0 mg/kg); (3) fentanyl (0.00625 - 0.0125 - 0.025 - 0.05 mg/kg), (4) 40% aqueous ethanol solution (0.5 - 1.0 - 2.0 - 4.0 g/kg), (5) ethaminal sodium (2.5 - 5 - 10 - 20(More)