Alexander A.F. Gann

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Withdrawal from the cell cycle is an essential aspect of vertebrate muscle differentiation and requires the retinoblastoma (Rb) protein that inhibits expression of genes needed for cell cycle entry. It was shown recently that cultured myotubes derived from the Rb-/- mouse reenter the cell cycle after serum stimulation (Schneider, J.W., W. Gu, L. Zhu, V.(More)
Cells detect extracellular signals by allostery and then give those signals meaning by 'regulated localization'. We suggest that this formulation applies to many biological processes and is particularly well illustrated by the mechanisms of gene regulation. Analysis of these mechanisms reveals that regulated localization requires simple molecular(More)
In 1980 Mark Ptashne published a review entitled How λ repressor and Cro work followed by another, in 1988, called How eukaryotic transcriptional activators work. The bold — almost, some might feel, naïve — ambition these titles betray is unashamedly the author's: to generate a coherent picture of how genes are switched on and off. Mark Ptashne's approach(More)
In 1980 Mark Ptashne published a review entitled How λ repressor and Cro work followed by another, in 1988, called How eukaryotic transcriptional activators work. The bold — almost, some might feel, naïve — ambition these titles betray is unashamedly the author's: to generate a coherent picture of how genes are switched on and off. Mark Ptashne's approach(More)