Alex Vainshtein

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Expanding on a quinazoline scaffold, we developed tricyclic compounds with biological activity. These compounds bind to the 18 kDa translocator protein (TSPO) and protect U118MG (glioblastoma cell line of glial origin) cells from glutamate-induced cell death. Fascinating, they can induce neuronal differentiation of PC12 cells (cell line of pheochromocytoma(More)
Recent knockout studies in mice have heightened interest in the 18-kDa translocator protein (TSPO) as a target for drug treatment of various diseases. 1 Although TSPO function may be inconspicuous in health, various studies have suggested TSPO may be relevant for responses to stress, disease, and injury. 2,3 In addition, TSPO was found necessary for(More)
The 18 kDa translocator protein (TSPO) is highly 0conserved in eukaryotes and prokaryotes. Since its discovery in 1977, numerous studies established the TSPO's importance for life essential functions. For these studies, synthetic TSPO ligands typically are applied. Tetrapyrroles present endogenous ligands for the TSPO. Tetrapyrroles are also evolutionarily(More)
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