Alex Steinleitner

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OBJECTIVE To determine by reverse transcription-polymerase chain reaction (PCR) whether human leukocyte antigen (HLA) class I messenger RNA (mRNA) is present in mature human spermatozoa. DESIGN Mature human spermatozoa was isolated from donor semen using a swim-up technique. Total RNA was extracted via guanidinium isothiocyanate-cesium chloride(More)
OBJECTIVE To evaluate the efficacy of low-dose intravenous immunoglobulin (IVIG) treatment in older women with immunologic abnormalities and recurrent spontaneous abortion (RSA), a condition referred to as immunologic abortion. DESIGN Prospective clinical trial. SETTING Outpatient referral practice. PATIENT(S) Forty-seven women were enrolled in the(More)
A loudspeaker is moved from a position beside the subject to a position vertically above the subject's head. The subject's head is either in the normal upright position (= 0 degrees) or the head (and body) is tilted 30 degrees or 60 degrees to the left. The subject estimates the sound as vertical (=auditory subjective vertical, ASV) before it reaches the(More)
Current evidence suggests that peritoneal inflammatory cell hyperactivation may be the essential pathologic abnormality in patients with endometriosis-associated subfertility. In these experiments we utilized an animal model to evaluate the use of an immunomodulatory agent as an alternative treatment for endometriosis-associated subfertility. The right(More)
OBJECTIVE To determine the effect of pentoxifylline on early reproductive performance in an animal model for endometriosis. DESIGN Preclinical blinded study in a rodent model. SETTING Animal research laboratory. PARTICIPANTS Sexually mature female golden hamsters. INTERVENTIONS At laparotomy, groups of hamsters were subjected to: (1) excision of the(More)
Although present consensus holds that endometriosis-associated subfertility is the result of an adverse effect of hyperactivated macrophages on early reproductive events, most treatments for endometriosis are directed at the suppression of endometriotic implants. We hypothesized that periovulatory immunomodulation of macrophage activation and inflammatory(More)
Current thought in reproductive endocrinology suggests hat endometriosis-associated subfertility may be the result of an adverse influence of activated immunocompetent cells on fertilization and embryo development. Inflammatory ediators such as interleukin-1 and tumour necrosis actor have been implicated in the pathophysiology of this process. The purpose(More)
Both Flowgel and Interceed(TC7) effectively inhibited postsurgical adhesion formation in the rabbit model. Given the unique handling characteristics of Flowgel, this material may have significant potential for use as an adjuvant in laparoscopic infertility procedures.
Alphoid repeat sequences on the X and Y chromosomes were successfully and consistently coamplified to determine the sex of single cells. Buccal cells served as a convenient model for single blastomeres obtained from preimplantation embryos through in vitro fertilization. The potential use of this technique for preimplantation genetic diagnosis is discussed.
Ovarian hyperstimulation syndrome (OHS) is one of the potential complications associated with the use of human menopausal gonadotropin therapy. We recently dealt with a case of severe OHS presenting features of liver dysfunction; such a case has not been reported on before.