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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo
Multiple sclerosis involves an aberrant autoimmune response and progressive failure of remyelination in the central nervous system. Prevention of neural degeneration and subsequent disabilityExpand
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MSC Therapeutics in Chronic Inflammation
The utilization of mesenchymal stem cells (also known as mesenchymal stromal cells (MSCs)) as a cell-based therapy for diseases that have ongoing inflammatory damage has become increasinglyExpand
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CNS disease diminishes the therapeutic functionality of bone marrow mesenchymal stem cells
Abstract Mesenchymal stem cells (MSCs) have emerged as a potentially powerful cellular therapy for autoimmune diseases including multiple sclerosis (MS). Based on their success in treating animalExpand
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Transcriptional Profiling of Mesenchymal Stem Cells Identifies Distinct Neuroimmune Pathways Altered by CNS Disease
Background and Objectives Bone marrow mesenchymal stem cells (BM-MSCs) are an attractive cell based therapy in the treatment of CNS demyelinating diseases such as multiple sclerosis (MS). PreclinicalExpand
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Important considerations for cell therapy manufacturing of mesenchymal stem cell
Background & Aim Recent advances in cell therapy manufacturing, e.g. microcarrier-based 3D culture and perfusion, have paved the way for cost-effective large-scale expansion of mesenchymal stem cellsExpand