Alex Sánchez

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BACKGROUND Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an(More)
Many gene identification methods assign scores to gene elementsas a previous step to their assembly in predicted genes. The scoring system is often based on log likelihood ratios (LLRs) whose meaning is somehow different from the usual likelihood ratio tests that appear in many statistical problems. In the first part of this work we have tried to give an(More)
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