Learn More
The natural environment is composed of various potentially hostile stressors. It is a basic requirement of life that the cells of an organism must be maintained within closely defined physiological limits. The maintenance of a constant interior mileu results from physiological and behavioural homeostatic adaptations. The physiological regulation of(More)
BACKGROUND Exaggerated postprandial lipemia (PPL) is a factor in atherogenesis, involving endothelial dysfunction and enhanced oxidative stress. We examined the effect of ciprofibrate therapy on these parameters in type 2 diabetes mellitus. METHODS AND RESULTS Twenty patients entered a 3-month, double-blind, placebo-controlled study. Each subject was(More)
Whole-cell recordings from rat cortical neurons in dissociated cell culture were used to study the antagonism of glutamate receptors by several lipophilic benzazepine analogues of 2,5-dihydro-2,5-dioxo-3-hydroxy-1H-benzazepine (DDHB). DDHB and three substituted derivatives, 4-bromo-, 7-methyl-, and 8-methyl-DDHB, inhibited the activation of(More)
Polymorphism in a DNA sequence has been observed on the 3'-flanking region of the human apoprotein-A-1 gene. The frequency of the heterozygous state in a healthy control population (n = 73) is around 0.05. However, 12 (frequency 0.34) out of 35 subjects with hypertriglyceridaemia were found to have the polymorphic site, and 2 were homozygous for this(More)
Low-density-lipoprotein (LDL) apheresis has the theoretical advantage over anion-exchange resins and hydroxymethylglutaryl coenzyme A inhibitors of decreasing lipoprotein(a) as well as LDL. To confirm this advantage, patients with heterozygous familial hypercholesterolaemia and coronary artery disease were randomised to receive LDL apheresis fortnightly(More)
The effect of starvation on the corticosterone responses of immature cockerels to acute, novel stress has been determined. The marked corticosterone responses of fed birds to either horizontal treadmill exercise (0.04 km/hr) or intravenous adrenocorticotrophic hormone (ACTH) administration (P less than 0.001 in both cases) were reduced by starvation (P less(More)
The influence of long-distance flight on corticosterone secretion has been examined in trained racing pigeons. Flights of 315-561 min from release sites 115-557 km from the home loft greatly increased the circulating corticosterone concentration in comparison with the levels in nonexercised controls sampled before release or bled in the loft at the times of(More)
Voluntary flight has previously been observed to stimulate adrenocortical activity in pigeons and in the present study increased circulating corticosterone levels were observed in adult feral pigeons forced to exercise in a treadwheel. The magnitude of the corticosterone response to treadwheel exercise was related to the speed of the moving drum, and hence(More)