Alex Posada

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During the development of the nervous system, a large number of neurons are eliminated through naturally occurring neuronal death. Many morphological and biochemical properties of such dying neurons are reminiscent of apoptosis, a type of death involving the action of genetically-programmed events but also epigenetic phenomena including oxidative stress.(More)
About half the neurons in the brain die at the time when their connections are being formed. This neuronal death is regulated by anterograde and retrograde signals that reflect both electrical activity and the uptake of trophic factors. Our recent data on the isthmo-optic projection indicate that there are in fact two different retrograde signals: a(More)
Two retrograde signals influence the chick embryo's isthmo-optic nucleus, which projects to the retina: a slow-acting survival signal due to uptake of neurotrophic factors, and a fast-acting death signal initiated by calcium entry into isthmo-optic terminals due to electrical activity. The latter signal also affects dendritic reorganization. Since nitric(More)
During the last decades, the relationship between technology and people has been continuously changing; the first computers and cnc machines appeared at the middle 50's, personal computers on the 70's, the popularization of Internet on the 90's, and more recently the smartphones (which combine both), produced an evolution on how and for what we are using(More)
Retrograde signals from axon terminal to cell body are known to regulate neuronal survival and differentiation during development. They are generally attributed to the uptake and transport of trophic factors, but there is recent evidence in the isthmo-optic nucleus for a remarkably fast-acting retrograde signal from the contralateral retina that is not(More)
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