Alex Mackenzie

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Vaccination has been proposed for the prevention of disease due to enterohemorrhagic Escherichia coli (EHEC), but the immune response following human infection, including the choice of potential antigens, has not been well characterized. To study this, sera were obtained from five pediatric patients with acute diarrhea caused by E. coli O157:H7 0, 8, and 60(More)
Rare diseases are not that rare: worldwide, one in 12-17 people will be affected by a rare disease. Newborn screening for rare diseases has been adopted by many European and North American jurisdictions. The results of genetic testing are given to millions of families and children's guardians who often turn to the In-ternet to find more information about(More)
ii Preface Biomedical NLP deals with the processing of healthcare-related text—clinical documents created by physicians and other healthcare providers at the point of care, scientific publications in the areas of biology and medicine, and consumer healthcare text such as social media blogs. Recent years have seen dramatic changes in the types and amount of(More)
BACKGROUND Patient registries represent an important method of organizing "real world" patient information for clinical and research purposes. Registries can facilitate clinical trial planning and recruitment and are particularly useful in this regard for uncommon and rare diseases. Neuromuscular diseases (NMDs) are individually rare but in aggregate have a(More)
Haemophilus influenzae type b (HIb) is the most common cause of bacterial meningitis in children with a mortality rate ranging from 1.6% to 14%. Most patients have a 2-3 day history of symptoms prior to admission. A few have fulminating disease with rapid neurological deterioration. Review of 191 cases of HIb meningitis revealed a mortality rate of 2.1% but(More)
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