Alex J. Walker

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BACKGROUND & AIMS All oral direct acting antivirals (DAAs) effectively treat chronic hepatitis C virus (HCV) infection, but the benefits in advanced liver disease are unclear. We compared outcomes in treated and untreated patients with decompensated cirrhosis. METHODS Patients with HCV and decompensated cirrhosis or at risk of irreversible disease were(More)
BACKGROUND Accurate population-based data are needed on the incidence of venous thromboembolism (VTE) in patients with different cancers in order to inform guidelines on which hospitalised and ambulatory cancer patients should receive VTE prophylaxis. METHODS We conducted a cohort study using data from the Clinical Practice Research Datalink, linked to(More)
Background:Several studies suggest links between cancer and tricyclic antidepressant use.Methods:A case–control study using the General Practice Research Database examined whether previous tricyclic usage was associated with reduced incidence of brain (with glioma as a sub-category), breast, colorectal, lung and prostate cancers. Conditional logistic(More)
Background:Aspirin has been widely reported to reduce the incidence of colorectal cancer. Recently, a survival benefit after diagnosis has also been suggested. Data regarding such a benefit are to date contradictory. This study examines the effect of non-steroidal anti-inflammatory drug (NSAID) use on mortality in colorectal cancer in a larger patient(More)
BACKGROUND & AIMS Direct-acting antivirals have become widely used for patients with chronic hepatitis C virus infection with decompensated cirrhosis. Virological responses are excellent and early improvements in liver function, at least in a proportion of patients, have been observed but the longer term impact of viral clearance on end-stage liver disease(More)
nean countnes, such as Greece. In the same country. as in the UK (Cancer Statistics Group, 1982). rates vary regionally. Thev can also vary even between adjacent districts. as in Scotland (Kemp et al.. 1985). Incidence and mortality rates are rising in many countries (Davis et al.. 1990: Dofl, 1990). However, survival rates are improving (Bonnett et al..(More)
BACKGROUND Patients with colorectal cancer are at high risk of developing venous thromboembolism(VTE), and recent international guidelines have advised extended prophylaxis for some of these patients following surgery or during chemotherapy. However, our understanding of which patients are at increased risk, and to what extent, is limited. OBJECTIVES To(More)
In a series of South African populations, mean faecal pH values were found to be: rural and urban blacks, 6.12 and 6.15; Indians 6.21; coloureds (Eur-African-Malay), 6.29; these are significantly lower (p less than 0.01) than that of whites, 6.88. Apart from that of the coloureds, mean values for series of children and adults did not differ significantly.(More)
OBJECTIVES Mortality from ruptured abdominal aortic aneurysm (RAAA) remains high. Despite this, withholding surgery on poor-prognosis patients with RAAA may create a difficult dilemma for the surgeon. Hardman et al. identified five independent, preoperative risk factors associated with mortality and proposed a model for preoperative patient selection. The(More)
Patients with breast cancer are at increased risk of venous thromboembolism (VTE), particularly in the peridiagnosis period. However, no previous epidemiologic studies have investigated the relative impact of breast cancer treatments in a time-dependent manner. We aimed to determine the impact of breast cancer stage, biology, and treatment on the absolute(More)