Learn More
A major goal of neuroscience is to understand the relationship between neural structures and their function. Recording of neural activity with arrays of electrodes is a primary tool employed toward this goal. However, the relationships among the neural activity recorded by these arrays are often highly complex making it problematic to accurately quantify a(More)
An understanding of the in vivo spatial emergence of abnormal brain activity during spontaneous seizure onset is critical to future early seizure detection and closed-loop seizure prevention therapies. In this study, we use Granger causality (GC) to determine the strength and direction of relationships between local field potentials (LFPs) recorded from(More)
While temporal lobe epilepsy (TLE) has been treatable with anti-seizure medications over the past century, there still remain a large percentage of patients whose seizures remain untreatable pharmacologically. To better understand and treat TLE, our laboratory uses several in vivo analytical techniques to estimate connectivity in epilepsy. This paper(More)
Botulinum toxin (BoNT) is a potent neurotoxin produced by toxigenic strains of Clostridium botulinum. Botulinum toxin poses a major threat since it could be employed in a deliberate attack on the U.S. food supply. Furthermore, BoNT may be liberated in any insufficiently processed food containing a reduced oxygen atmosphere. Hence, rapid and reliable(More)
Delivery of pharmacological agents in vitro can often be a difficult, time consuming and costly process. In this paper, we describe an economical method for in vitro delivery using a hydrogel of poly hydroxyethyl methacrylate (PHEMA) that can absorb up to 50% of its weight of any water-solubilized pharmacological agent. This agent will then passively(More)
In this paper we present three related areas of research we are pursuing to study neural computation in vitro. Rat cortical neurons cultured on 60 channel multielectrode array (MEA) allow the researcher to measure from and stimulate sixty different sites across a small population of neurons grown in vitro. Using this system we can send stimulation patterns(More)
2 To my Mom and Dad, for their love and support 3 ACKNOWLEDGMENTS This project could be accomplished only with the outstanding guidance and patience and generous support of my mentor Dr.Mingzhou Ding to whom I am deeply indebted for imbibing in me an exceptional perspective on highest quality research, and also for his constant encouragement and(More)
  • 1