Alex Hoekstra

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A limb defect in rabbits known as splayleg arose in a closed breeding colony of Dutch rabbits. Since the causes of this postural deformity are not fully understood, an effort was made to clarify the mode of inheritance and the etiology of the disease. Pedigree analysis and genetic mating tests showed that, in contrast to published reports, the disease is(More)
The field of regenerative medicine can be defined by its unique objectives: to restore and recover – rather than merely repair or preserve – damaged tissue. Stem cells offer a means of achieving this goal, but broadly-applicable scalability has been limited by numerous challenges including availability, purity, tissue development potential and(More)
Most in vitro studies of human endothelial cells have relied on cells derived from human umbilical veins (HUVEC); however, heterogeneity of primary cultured endothelial cells can make critical interpretation of results difficult. Several endothelial cell lines have been produced to serve as a more constant source of endothelial cells. In this study, we(More)
The induction of sister-chromatid exchanges (SCEs) by cyclophosphamide (CP) in human, rat and rabbit lymphocytes was studied in vitro without exogenous metabolic activation. In contrast with published reports, CP induced SCEs in lymphocytes from all three species, indicating that cultured lymphocytes possess the metabolic capacity to convert this(More)
This paper confirms the mutagenicity of 2 carcinogenic chemicals, o-tolidine and 4,4'-tetramethyldiaminodiphenylmethane (TDDM). o-Tolidine and TDDM were both tested in the Salmonella/mammalian-microsome test and in the sister-chromatid exchange (SCE) test with rabbit lymphocytes in vitro. The number of revertants was increased in the presence of S9 mix by(More)
Reports have appeared in the literature on brain cysts in rabbit foetuses. This paper reports on investigations carried out to assess whether "cystic dilatation" is a malformation or an artefact. The results show that "cystic dilatation" arises by splitting of the pia-arachnoid membrane leading to a space between the skull and the neural tissue which is(More)
In the assessment of drug safety with respect to mammalian reproductive function chlorpromazine and two serotonin antagonists, mianserin (Org GB94 ) and Org GC94 were studied for their effects on ovulation and ovum transport. In addition, the effect of coitus on drug-induced ovulation inhibition was investigated. The compounds were intragastrically(More)
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