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We present a statistical mechanics treatment of the stability of globular proteins which takes explicitly into account the coupling between the protein and water degrees of freedom. This allows us to describe both the cold and the warm unfolding, thus qualitatively reproducing the known thermodynamics of proteins. The folded conformation of globular(More)
We study the multifractal properties of the current distribution of the three-dimensional random resistor network at the percolation threshold. For lattices ranging in size from 8 3 to 80 3 we measure the second, fourth and sixth moments of the current distribution, finding e.g. that t/ν = 2.282(5) where t is the conductivity exponent and ν is the(More)
BACKGROUND/AIMS Genetic studies have raised the possibility of common bases for cognitive linguistic disorders such as speech sound disorder (SSD), reading disorder (RD) and language impairment (LI). Thus, some of the same genes may jointly influence cognitive components within and between these three disorders. We examined the plausibility of this theory(More)
We review a statistical mechanics treatment of the stability of globular proteins based on a simple model Hamiltonian taking into account protein self interactions and protein-water interactions. The model contains both hot and cold folding transitions. In addition it predicts a critical point at a given temperature and chemical potential of the surrounding(More)
The statistics of damage avalanches during a failure process typically follows a power law. When these avalanches are recorded only near the point at which the system fails catastrophically, one finds that the power law has an exponent which is different from that one finds if the recording of events starts away from the vicinity of catastrophic failure. We(More)
We study the size distribution of power blackouts for the Norwe-gian and North American power grids. We find that for both systems the size distribution follows power laws with exponents −1.65 ± 0.05 and −2.0 ± 0.1 respectively. We then present a model with global redistribution of the load when a link in the system fails which reproduces the power law from(More)
We review limiting models for fracture in bundles of fibers, with statistically distributed thresholds for breakdown of individual fibers. During the breakdown process, avalanches consisting of simultaneous rupture of several fibers occur, and the distribution D(∆) of the magnitude ∆ of such avalanches is the central characteristics in our analysis. For a(More)
Technical details are given on how to use Fourier acceleration with iterative processes such as relaxation and conjugate gradient methods. These methods are often used to solve large linear systems of equations, but become hopelessly slow very rapidly as the size of the set of equations to be solved increases. Fourier acceleration is a method designed to(More)
We propose a protein model based on a hierarchy of constraints that force the protein to follow certain pathways when changing conformation. The model exhibits a first order phase transition, cooperativity and is exactly solvable. It also shows an unexpected symmetry between folding and unfolding pathways as suggested by a recent experiment. Proteins(More)