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Inhibition of the ATPase activity of the chaperone protein HSP90 is a potential strategy for treatment of cancers. We have determined structures of the HSP90alpha N-terminal domain complexed with the purine-based inhibitor, PU3, and analogs with enhanced potency both in enzyme and cell-based assays. The compounds induce upregulation of HSP70 and(More)
We present a first application of a general approach to learn the behavior of NPCs (and other entities) in a game from observing just the graphical output of the game during game play. This allows some understanding of what a human player might be able to learn during game play. The approach uses object tracking and situation-action pairs with the(More)
We present type preserving bijections between noncrossing and nonnesting partitions for all classical reflection groups, answering a question of Athanasiadis and Reiner. The bijections for the abstract Coxeter types B, C and D are new in the literature. To find them we define, for every type, sets of statistics that are in bijection with non-crossing and(More)
We introduce the notion of a matroid M over a commutative ring R, assigning to every subset of the ground set an R-module according to some axioms. When R is a field, we recover matroids. When R = Z, and when R is a DVR, we get (structures which contain all the data of) quasi-arithmetic matroids, and valuated matroids, respectively. More generally, whenever(More)