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Leptin plays an important role in regulation of body weight through regulation of food intake and sympathetically mediated thermogenesis. The hypothalamic melanocortin system, via activation of the melanocortin-4 receptor (MC4-R), decreases appetite and weight, but its effects on sympathetic nerve activity (SNA) are unknown. In addition, it is not known(More)
We present a graph-theoretic model of discourse based on the Questions Under Discussion (QUD) framework. Questions and assertions are treated as edges connecting discourse states in a rooted graph, modeling the introduction and resolution of various QUDs as paths through this graph. The amount of common ground presupposed by interlocutors at any given point(More)
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