• Publications
  • Influence
HO-3867, a Synthetic Compound, Inhibits the Migration and Invasion of Ovarian Carcinoma Cells through Downregulation of Fatty Acid Synthase and Focal Adhesion Kinase
TLDR
The results showed that HO-3867 suppressed the migration and invasion of ovarian cancer cells by inhibiting the expression or activity of FAS and FAK proteins. Expand
Amelioration of Doxorubicin-Induced Cardiotoxicity by an Anticancer-Antioxidant Dual-Function Compound, HO-3867
TLDR
The study indicates that combination treatment of HO-3867 and DOX is a viable option for treatment of cancer with reduced cardiotoxic side effects. Expand
Pappa2 is linked to salt-sensitive hypertension in Dahl S rats.
TLDR
A variant form of Pappa2 that can protect against salt-induced hypertension in the Dahl S rat is identified and found localized in the cytosol of the epithelial cells of the cortical thick ascending limbs. Expand
Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells.
TLDR
A novel class of bifunctional compounds based on diarylidenyl piperidone conjugated to an N-hydroxypyrroline (NOH; a nitroxide precursor) group suggests that the antioxidant-conjugated DAPs will be useful as safe and effective anticancer agents for cancer therapy. Expand
HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition
TLDR
The combination treatment significantly inhibited the growth of cisplatin-resistant xenograft tumors with significant downregulation of pSTAT3, and without apparent toxicity to healthy tissues, suggesting the potential use of this compound as a safe and effective adjuvant for the treatment of ovarian cancer. Expand
Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats
TLDR
It is concluded that the reduced renal injury and attenuated blood pressure response to high salt in the SSNox4−/− rat could be the result of multiple pathways, including gene transcription, mitochondrial energetics, oxidative stress, and protein matrix production impacted by the knock out of Nox4. Expand
Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections.
TLDR
This study presents a novel and robust application of convolutional neural nets for the localization of glomeruli in healthy and damaged trichrome-stained whole-renal section mounts and lays the groundwork for automated glomerular injury scoring. Expand
Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties
TLDR
The results suggest that the DAP analog, HO-3867, has substantially higher bioabsorption when compared to curcumin, a naturally-occurring compound found in the rhizome of Curcuma longa plant. Expand
Therapeutic Suppression of mTOR (Mammalian Target of Rapamycin) Signaling Prevents and Reverses Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive Rats
TLDR
The results indicate that mTORC2 and the related downstream associated pathways play an important role in regulation of sodium balance and arterial pressure regulation in salt-sensitive rats. Expand
Breaking the Cycle: Estrous Variation Does Not Require Increased Sample Size in the Study of Female Rats
TLDR
Variation of 142 traits in male and female rats is similar, suggesting that differential treatment of males and females for the purposes of experimental design is unnecessary until proven otherwise, rather than the other way around. Expand
...
1
2
3
...