Alex Davies

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Sensory hair cells in the ear and lateral line have an asymmetrical hair-bundle structure, essential for their function as directional mechanotransducers. We examine four questions: (1) how does the planar asymmetry of the individual hair cell originate? (2) How are the orientations of neighboring hair cells coordinated? (3) How is the orientation of a(More)
I, DAVID ARTHUR KNOWLES, confirm that this dissertation is the result of my own work and includes nothing which is the outcome of work done in collaboration except where specifically indicated in the text. Where information has been derived from other sources, I confirm that this has been indicated in the thesis. I also confirm that this thesis is below(More)
The Internet has enabled the creation of a growing number of large-scale knowledge bases in a variety of domains containing complementary information. Tools for automatically aligning these knowledge bases would make it possible to unify many sources of structured knowledge and answer complex queries. However, the efficient alignment of large-scale(More)
We present Random Partition Kernels, a new class of kernels derived by demonstrating a natural connection between random partitions of objects and kernels between those objects. We show how the construction can be used to create kernels from methods that would not normally be viewed as random partitions, such as Random Forest. To demonstrate the potential(More)
b Acknowledgements I would like to thank Carl Rasmussen for advice throughout my PhD; Steven Bottone for extensive proof reading; Marc Deisenroth for assisting me in acquiring his L A T E X skills. I acknowledge my examiners Zoubin Ghahramani (internal) and Amos Storkey (external). I would like to thank my co-authors in the publications leading up to my(More)
INTRODUCTION The primary goal of stereotactic systems in deep brain stimulation (DBS) surgery is accurate delivery of a DBS lead to a target identified on imaging. Thus, it is critical to understand the accuracy of the stereotactic systems and the factors which may be associated with a decrease in accuracy. METHODS Ninety patients underwent microelectrode(More)
Detailed observations of larval Drosophila chemotaxis have characterised the relationship between the odour gradient and the runs, head casts and turns made by the animal. We use a computational model to test whether hypothesised sensorimotor control mechanisms are sufficient to account for larval behaviour. The model combines three mechanisms based on(More)