Alex D Cooper

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OBJECTIVE To determine the functional and cognitive outcomes of patients with prolonged refractory status epilepticus (PRSE) lasting 7 or more days despite the use of anesthetic agents for seizure suppression. DESIGN Retrospective analysis. SETTING St Mary's Hospital, Mayo Clinic, Rochester, Minnesota. PARTICIPANTS Fourteen patients with PRSE. (More)
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) have overlapping clinical features that can make clinical distinction between these two entities difficult. The present study compared the frequency of photophobia, visual hallucinations, and REM sleep behavior disorder (RBD) in patients clinically diagnosed with PSP to those(More)
A 59-year-old man with a family history of cerebral cavernous malformations (CCM) presented with focal seizures. T2*-weighted gradient echo (GRE) images showed multiple lesions consistent with cavernous malformations (figure 1). Susceptibility-weighted images (SWI) detected nearly triple the number of lesions than were seen with the GRE sequence (figure 2).(More)
The incidence of mumps cases has declined dramatically since the introduction of the measles, mumps, rubella vaccine. A recent outbreak, however, brings to attention the importance of recognizing the clinical symptoms and signs of mumps, because early isolation of patients may prevent spread of the disease. The authors present the case of a 50-year-old man(More)
Pulmonary complications represent the leading cause of postoperative morbidity. Thoracic surgical procedures carry the highest risk of such complications. Prevention of pulmonary morbidity in thoracic surgical patients depends on an understanding of expected pulmonary pathophysiologic changes, preoperative assessment of patient risk, and specific(More)
Debrisoquin undergoes oxidative metabolism to 4-hydroxydebrisoquin, catalyzed by cytochrome CYP2D1 in rats and CYP2D6 in humans. Cytochrome CYP2D6 also plays a major role in dextromethorphan O-demethylation. In preliminary studies in perfused Lewis rat livers, we observed a difference in repeat clearance experiments using debrisoquin, but not(More)
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