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OBJECTIVE To highlight emerging evidence for clinical and biological links between autism/pervasive developmental disorder (PDD) and schizophrenia, with particular attention to childhood-onset schizophrenia (COS). METHOD Clinical, demographic, and brain developmental data from the National Institute of Mental Health (and other) COS studies and selected(More)
Earlier studies revealed progressive cortical gray matter (GM) loss in childhood-onset schizophrenia (COS) across both lateral and medial surfaces of the developing brain. Here, we use tensor-based morphometry to visualize white matter (WM) growth abnormalities in COS throughout the brain. Using high-dimensional elastic image registration, we compared 3D(More)
We explored regional and total volumetric cerebellar differences in probands and their unaffected full siblings relative to typically developing participants. Participants included 94 (51 males) patients diagnosed with childhood onset schizophrenia (COS), 80 related non-psychotic siblings (37 males) and 110 (64 males) typically developing participants(More)
BACKGROUND Little is known about the effects of antipsychotic medications on gray matter (GM) in schizophrenia. Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development. METHODS In an exploratory analysis, we used automated cortical thickness(More)
While computational cognitive modeling has made great strides in addressing complex dynamic tasks, the modeling of individual differences in complex tasks remains a largely unexplored area of research. In this paper we present a straightforward approach to modeling individual differences, specifically age-related cognitive differences, in complex tasks, and(More)
CONTEXT Nonpsychotic siblings of patients with childhood-onset schizophrenia (COS) share cortical gray matter abnormalities with their probands at an early age; these normalize by the time the siblings are aged 18 years, suggesting that the gray matter abnormalities in schizophrenia could be an age-specific endophenotype. Patients with COS also show(More)
Subjects communicated prior to playing trust games; the richness of the communication media and the topics of conversation were manipulated. Communication richness failed to produce significant differences in first-mover investments. However, the topics of conversation made a significant difference: the amounts sent were considerably higher in the(More)
Metagames (Howard, 1968), a class of formal models in game theory, model the strategic reasoning among players who mutually predict each others actions recursively (" I think you think I think. .. "). We present a framework for three-player games based on metagame theory. This framework is well-suited to the analysis of nation-states, especially when the(More)