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Contrast sensitivity (CS) is often used to assess spatial and temporal vision in animals. Conventional behavioral psychophysical techniques are both time and labor intensive, whereas measurement of CS functions by means of the pattern electroretinogram (PERG) is considerably more rapid and efficient. Are the two methods comparable, however? To answer this(More)
Spatiotemporal contrast sensitivity (CS) functions were obtained from four White Carneaux pigeons. The spatial frequency for each session was selected randomly from a group of five spatial frequencies ranging from 0.42 to 1.26 c/deg. Within the session, the temporal frequency varied from 1 to 32 Hz. When plotted as a function of spatial frequency, the CS(More)
Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) superfamily ligands to regulate the expression of target genes. In order to identify novel partners of Smad proteins in transcriptional regulation, we performed a two-hybrid screen using Smad5, a protein that is activated predominantly by bone morphogenetic protein (BMP)(More)
The neuropeptide galanin modulates several physiological functions such as cognition, learning, feeding behavior, and depression, probably via the galanin 1 receptor (GAL-R1). Using an HTS assay based on 125I-human galanin binding to the human galanin-1 receptor (hGAL-R1), we discovered a series of 1,4-dithiin and dithiipine-1,1,4,4-tetroxides that(More)
NOTICE This report was prepared as an account of work sponsored by an agency of the United States government. Neither the United States government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information,(More)
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