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The neurotrophin receptor TrkA plays critical roles in the nervous system by recruiting signaling molecules that activate pathways required for the growth and survival of neurons. Here, we report APPL1 as a TrkA-associated protein. APPL1 and TrkA co-immunoprecipitated in sympathetic neurons. We have identified two routes through which this association can(More)
There is a growing public perception that intergenerational income mobility—a child's chance of moving up in the income distribution relative to her parents—is declining in the United States. We present new evidence on trends in intergenerational mobility using administrative earnings records for children born between 1971 and 1993. For the 1971–1986 birth(More)
PURPOSE To assess the relationship between helical dynamic contrast material-enhanced (DCE) computed tomographic (CT) parameters and immunohistochemical markers of hypoxia in patients with operable non-small cell lung cancer (NSCLC). MATERIALS AND METHODS After institutional review board approval was obtained, 20 prospective patients who were suspected of(More)
The B6dom1 minor histocompatibility antigen (MiHA) is a model antigen, since it is both the epitome of an immunodominant epitope and an ideal target for adoptive cancer immunotherapy. Based on DNA sequencing and MS/MS analyses, we report that B6dom1 corresponds to amino acids 770–778 (KAPDNRETL) of a protein we propose to call SIMP (source of immunodominant(More)
BACKGROUND Surveillance endomyocardial biopsies (EMBs) are used for the early diagnosis of acute cardiac allograft rejection. Protocols became standardized in an earlier era and their utility with contemporary immunosuppression has not been investigated. METHODS We studied 258 patients after orthotopic heart transplantation comparing 135 patients(More)
Sirolimus (rapamycin) and everolimus are immunosuppressive agents that inhibit cardiac allograft vasculopathy. Sirolimus has been widely used in renal transplantation, and its use in heart transplantation is increasing. Sirolimus-associated pneumonitis has been described in renal transplant patients. Two cases of sirolimus-associated pneumonitis have been(More)
Tandem mass spectrometry followed by data base search is the preferred method for protein identification in high throughput proteomics. However, standard analysis methods give rise to highly redundant lists of proteins with many proteins identified by the same sets of peptides. In essence, this is a list of all proteins that might be present in the sample.(More)
In this paper a experiment is presented in which two simulated robots evolved a form of communication to allow one of the robots to complete the task of finding a light placed in the world. The robots are constrained so that one has inputs about the world, seeing robot, and the other, blind robot, has no sensors besides an input from the seeing robot. The(More)
We have developed a united atom (UA) nonpolarizable force field for 1-alkyl-3-methyl-imidazolium chloride ([C(n)mim][Cl], n = 1, 2, 4, 6, 8), a potential solvent for the pretreatment of lignocellulosic biomass. The charges were assigned by fitting the electrostatic potential surface (ESP) of the ion pair dimers. The Lennard-Jones parameters of the hydrogen(More)