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  • Marival Bermejo, Alex Avdeef, +8 authors V. Baonza Merino
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 2004 (First Publication: 1 March 2004)
  • Parallel artificial membrane permeability assay (PAMPA) was used to measure the effective permeability, P(e), as a function of pH from 4 to 10, of 17 fluoroquinolones, including three congenericExpand
  • Alex Avdeef
  • Chemistry, Medicine
  • Advanced drug delivery reviews
  • 2007 (First Publication: 1 July 2007)
  • The experimental and computational basis of the pH-dependent measurement of solubility of sparingly-soluble ionizable drugs is reviewed. Recently described compound-sparing (but still accurate)Expand
  • Alex Avdeef, Per E. Nielsen, Oksana Tsinman
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 2004 (First Publication: 1 August 2004)
  • Many plate-based in vitro assays of membrane permeability (e.g., Caco-2, MDCK, PAMPA) of sparingly soluble candidate molecules report permeability of water, and not of the intended membrane barrier.Expand
  • Christel A. S. Bergström, Melissa Strafford, Lucia Lazorova, Alex Avdeef, Kristina Luthman, Per Artursson
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2003 (First Publication: 1 February 2003)
  • The aim of this study was to investigate whether easily calculated and comprehended molecular surface properties can predict drug solubility and permeability with sufficient accuracy to allowExpand