Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
- Su-Ju Lin, M. Kaeberlein, L. Guarente
- BiologyNature
- 18 July 2002
It is shown that the shunting of carbon metabolism toward the mitochondrial tricarboxylic acid cycle and the concomitant increase in respiration play a central part in this process that activates Sir2 to extend lifespan.
High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction
- M. Kaeberlein, Alex A. Andalis, G. Fink, L. Guarente
- BiologyMolecular and Cellular Biology
- 15 November 2002
Genetic and microarray analysis indicates that high osmolarity extends the life span by activating Hog1p, leading to an increase in the biosynthesis of glycerol from glycolytic intermediates, thereby activating Sir2p and promoting longevity.
Defects Arising From Whole-Genome Duplications in Saccharomyces cerevisiae
- Alex A. Andalis, Z. Storchová, C. Styles, T. Galitski, D. Pellman, G. Fink
- BiologyGenetics
- 1 July 2004
The data show that whole-genome duplications are accompanied by defects that affect viability and subsequent survival of the new organism, and that an increase in ploidy results in a marked decrease in a cell's ability to survive during stationary phase in growth medium.
Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism.
- M. Kaeberlein, Alex A. Andalis, Gregory B. Liszt, G. Fink, L. Guarente
- BiologyGenetics
- 1 April 2004
It is shown here that the SSD1-V allele is necessary for cells to achieve extremely long life span and addition of SSD 1-V to cells can increase longevity independently of SIR2, although SIR1 is necessary to attain maximal life span.
Saccharomyces cerevisiae SSD 1V Confers Longevity by a Sir 2 p-Independent Mechanism
- M. Kaeberlein, Alex A. Andalis, Gregory B. Liszt, G. Fink, L. Guarente
- Biology
- 2004
It is proposed that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggested that future studies on longevity-promoting genes should be carried out in long-lived SSD 1-V strains.