Alessio Innocenti

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A series of novel 4-substituted-3-pyridinesulfonamides (2-27 and 31-33) have been synthesized and investigated as inhibitors of five isoforms of zinc enzyme carbonic anhydrase (CA, EC, that(More)
Coumarins constitute a general and totally new class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC, binding at the entrance of the active site cavity. We report here that the(More)
A lately discovered carbonic anhydrase (hCA, EC, the mitochondrial hCA VB, was cloned, expressed, and purified. Kinetic parameters proved it to be 3.37 times more effective than hCA VA as a(More)
The β-carbonic anhydrase (CA, EC enzymes have been reported in a variety of organisms, but their existence in animals has been unclear. The purpose of the present study was to perform(More)