Alessia Finotti

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Involvement of miRNA in erythroid differentiation.

Nicoletta Bianchi, Cristina Zuccato, Alessia Finotti, Ilaria Lampronti, Monica Borgatti, Roberto Gambari
Epigenomics
2012

miRNAs are a family of small ncRNAs that regulate gene expression by targeting mRNAs in a sequence-specific manner, inducing translational repression or mRNA degradation. In this review, we present… (More)

Effects of rapamycin on accumulation of alpha-, beta- and gamma-globin mRNAs in erythroid precursor cells from beta-thalassaemia patients.

Eitan Fibach, Nicoletta Bianchi, +6 authors Roberto Gambari
European journal of haematology
2006

We studied the effects of rapamycin on cultures of erythroid progenitors derived from the peripheral blood of 10 beta-thalassaemia patients differing widely with respect to their potential to produce… (More)

Production of beta-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients.

Francesca Salvatori, Giulia Breveglieri, +11 authors Roberto Gambari
American journal of hematology
2009

In several types of thalassemia (including beta(0)39-thalassemia), stop codon mutations lead to premature translation termination and to mRNA destabilization through nonsense-mediated decay. Drugs… (More)

Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells.

Valentino Bezzerri, Monica Borgatti, Alessia Finotti, Anna Tamanini, Roberto Gambari, Giulio Cabrini
Journal of immunology
2011

IL-8 released from bronchial epithelial cells infected with Pseudomonas aeruginosa plays a crucial role in the chronic lung pathology of patients affected by cystic fibrosis. Novel anti-inflammatory… (More)

Targeting microRNAs involved in human diseases: a novel approach for modification of gene expression and drug development.

Roberto Gambari, Enrica Fabbri, +7 authors Roberto Corradini
Biochemical pharmacology
2011

The identification of all epigenetic modifications (i.e. DNA methylation, histone modifications and expression of noncoding RNAs such as microRNAs) involved in gene regulation is one of the major… (More)

Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression.

Michele Borgatti, Alessia Finotti, +10 authors Roberto Gambari
Current drug targets
2004

Peptide nucleic acids (PNAs)-DNA chimeras have been recently described as DNA mimics constituted of a part of PNA and of a part of DNA. We have demonstrated that double stranded molecules based on… (More)

Peptide nucleic acid-DNA decoy chimeras targeting NF-kappaB transcription factors: Induction of apoptosis in human primary osteoclasts.

Letizia Penolazzi, Monica Borgatti, +7 authors Roberto Gambari
International journal of molecular medicine
2004

Peptide nucleic acids (PNAs) are DNA mimics constituted by a pseudopeptide backbone composed of N-(2-aminoethyl)glycine units. PNAs hybridize with high affinity to complementary sequences of… (More)

Tobramycin is a suppressor of premature termination codons.

N. Altamura, Rosa Castaldo, +6 authors Monica Borgatti
Journal of cystic fibrosis : official journal of…
2013

Premature translation terminations (PTCs) constitute the molecular basis of many genetic diseases, including cystic fibrosis, as they lead to the synthesis of truncated non-functional or partially… (More)

Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin.

Alessia Finotti, Jessica Gasparello, +9 authors Roberto Gambari
Experimental hematology
2015

Induction of fetal hemoglobin (HbF) is considered a promising strategy in the treatment of β-thalassemia, in which production of adult hemoglobin (HbA) is impaired by mutations affecting the β-globin… (More)

Recent patents and technology transfer for molecular diagnosis of β-thalassemia and other hemoglobinopathies.

Giulia Breveglieri, Alessia Finotti, Monica Borgatti, Roberto Gambari
Expert opinion on therapeutic patents
2015

INTRODUCTION Biological tests and genetic analyses for diagnosis and characterization of hematological diseases in health laboratories are designed with the aim of meeting the major medical needs of… (More)

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