Alessandro Sartini

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The pathogenesis of inflammatory bowel diseases (IBDs) seems to involve a primary defect in one or more of the elements responsible for the maintenance of intestinal homeostasis and oral tolerance. The most important element is represented by the intestinal barrier, a complex system formed mostly by intestinal epithelial cells (IECs). IECs have an active(More)
Despite the increasing evidence of MAP/DNA isolation in Crohn’s disease (CD), its potential pathogenetic role remains unclear. To further clarify the possible relationship between MAP and CD, we investigated the presence of IS900 DNA fragment in feces from Crohn’s disease and ulcerative colitis (UC) patients and from healthy controls (HC). Stool samples(More)
BACKGROUND Curcuma has long been used as an anti-inflammatory agent in inflammatory bowel disease. Since gastrointestinal motility is impaired in inflammatory states, the aim of this work was to evaluate if Curcuma Longa had any effect on intestinal motility. METHODS The biological activity of Curcuma extract was evaluated against Carbachol induced(More)
Crohn's disease is a chronic transmural inflammatory disease that most commonly affects the intestinal wall, but may also occur in any part of the gastrointestinal tract; its incidence is higher in industrialized countries, urban areas and upper socioeconomic classes. Various environmental risk factors have been associated with the pathogenesis of Crohn's(More)
Ulcerative colitis and Crohn's disease are relapsing and remitting chronic disorders. So far, endoscopy is the gold standard for their diagnosis, but less invasive diagnostic biomarkers are needed. Many authors have developed techniques to individuate biomarkers such as genetic testing factor or proteins in biological samples such as serum, plasma, and(More)
Pouchitis is the most frequent complication after ileal pouch–anal anastomosis for refractory ulcerative colitis. A non-standardized preventative treatment exists. Sulfasalazine has proved effective in acute pouchitis therapy. The aim of this study was to retrospectively evaluate the effect of sulfasalazine in primary prophylaxis of pouchitis after(More)
We read with great interest the paper by Carr et al. [1] on the role of metabolic syndrome (MetS) and intestinal inflammation in the severity of nonalcoholic fatty liver disease (NAFLD) in patients with inflammatory bowel disease (IBD). They intercepted IBD patients with established NAFLD by using ICD-9 codes, finding that the majority of IBD patients (77%)(More)