Alessandro Salvi

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CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays crucial roles in CNS development and maintenance. CDK5 activity strongly depends on p35 levels and p35/CDK5 misregulation is deleterious for correct CNS function, suggesting that a tightly controlled regulation of CDK5R1 expression is needed for proper CDK5 activity.(More)
Smart cities and smart mobility represent two of the most significative real use case scenarios in which there is an increasing demand for collecting, elaborating, and storing large amounts of heteroge-nous data. In urban and mobility scenarios issues like data trustiness and data and network security are of paramount importance when considering smart(More)
microRNAs (miRs) are 18-25 nucleotide non-coding RNAs that regulate gene expression in several physiological and pathological conditions. To gather more knowledge on microRNAs in human hepatocellular carcinoma (HCC) we generated a small RNA library in the human HCC cell line HA22T/VGH by cloning and sequencing(More)
Hepatocellular carcinoma (HCC) is a challenging malignancy of global importance, it is the third most common cause of cancer-related mortality worldwide. In the last years the multikinase inhibitor sorafenib has been used for advanced HCC, but some patients do not benefit from this therapy; thus, novel therapeutic options based on molecular approaches are(More)
  • Davide De Pasquale, Pietro Marchetta, Eduard Natale, Alessandro Salvi, Antonio Tirri, Manuela Tufo
  • 2013
The main idea behind S2-Move, a social innovation project financed by the Italian Ministry of Education, Research and University, is to supply soft real-time information exchange among citizens, public administrations and transportation systems by exploiting Information and Communication Technologies. In this paper, we describe the technological S2-Move(More)
In human hepatocellular carcinoma (HCC), the high expression of urokinase-type plasminogen activator (uPA) is an unfavorable prognostic factor and a therapeutic target. To identify the downstream effects of uPA silencing by RNA interference, we studied proteome modifications of uPA-inhibited SKHep1C3 cells, an HCC-derived cell line. The study with(More)
—Automated and coordinated vehicles' driving (pla-tooning) is gaining more and more attention today and it represents a challenging scenario heavily relying on wireless Inter-Vehicular Communication (IVC). In this paper, we propose a novel controller for vehicle platooning based on consensus. Opposed to current approaches where the logical control topology(More)